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11 Mar, 26
New guidelines on pulmonary embolism (PE) offer evidence based recommendations for evaluating, managing, and following up adults with acute PE. Endorsed by eight societies, it stresses multidisciplinary care across emergency, inpatient, & outpatient settings.
26 Feb, 26
ADA 2026 outlines the standards for obesity pharmacotherapy. It recommends combining person-centered medication with lifestyle changes for adults with obesity. It details weight-loss targets and drug benefits for comorbidities
17 Mar, 26
J Glaucoma.
- In a TriNetX cohort (T1DM: N = 166,471; T2DM: N = 5,745,652), diabetic retinopathy (DR) was linked to higher risk of ocular hypertension (OHT)/ primary open angle glaucoma (POAG)
- T1DM with DR had 4.966-fold OHT risk & 4.262-fold POAG risk T2DM with DR showed 2.651-fold OHT risk & 2.62-fold POAG risk
- Risk was greater in PDR vs. NPDR, findings underscore vigilant screening & comprehensive management.
17 Mar, 26J Diabetes Sci Techn...
- The meta analysis of 16 studies (10 quantitative; n=1657) compared the CGM-derived metrics between prediabetics & normoglycemics
- Prediabetes was consistently linked to higher CGM metrics vs. normoglycemia: MAGE (MD 9.41 mg/dL), TAR% (MD 5.68%), & 24 h mean glucose (MD 7.91 mg/dL)
- This first quantitative evidence suggests that CGM discriminates prediabetes & normoglycemia, & can support refined risk assessment.
16 Mar, 26Endocrinol Diabetes ...
- A systematic review & meta-analysis of 23 RCTs compared SGLT 2i+metformin vs. other metformin containing oral dual therapies in T2DM
- HbA1c reduction was comparable at 24/52 weeks, at 52 weeks, patients on SGLT 2i+metformin had lower hypoglycemia risk (RR 0.27) & greater body weight reduction (MD –2.59 kg), but increased genital infection risk (RR 5.08)
- Other safety outcomes were comparable.
16 Mar, 26Lancet Infect Dis.
- Meta analysis showed that typhoid caused substantial morbidity; delirium/confusion occurred commonly (26.5%)
- Typhoid case fatality ratio (CFR) was 2.1% & typhoid intestinal perforation CFR was 16.3%; highest in Africa (4.7%), followed by America (2.9%) and Asia (1.2%)
- Higher typhoid CFR was seen in facility-based vs. community-based recruitment sites (2.3% vs. 0.9%) & among those aged <15y (2.7%)
2 Mar, 26
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