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22 Dec, 25
This updated guideline from major respiratory and infectious disease societies recommend shorter all‑oral regimens for drug‑susceptible and drug‑resistant tuberculosis (TB), including novel 4‑month treatments and bedaquiline‑based combinations.
17 Dec, 25
Global Consensus Statement addresses the epidemiology, diagnosis, and management of IBD in pregnancy, emphasizing preconception disease remission, high-risk pregnancy classification, and structured diagnostic monitoring. It supports individualized management with continuation of most standard and biologic therapies to maintain disease control, while identifying specific agents requiring discontinuation prior to conce...
22 Dec, 25
Lancet Infect Dis.
- The Global Burden of Diseases, Injuries, and Risk Factors Study 2023 estimated 2.50 million deaths and 98.7 million DALYs from lower respiratory infections (LRIs) in 204 countries
- S. pneumoniae caused 634k deaths (25%), S. aureus 271k (11%), and K. pneumoniae 228k (9%)
- Newly modelled pathogens, including non-tuberculous mycobacteria (177k) and Aspergillus spp (67.8k), together accounted for 22% of LRI deaths,
22 Dec, 25Hypertension.
- The SPRINT post hoc analysis (n=8985) examined the link between SBP time in target range (SBP TTR: 110–130 mmHg in intensive arm; 120–140 mmHg in standard arm, over 3 months) & AKI risk
- 258 AKI cases occurred (7.62/1000 person years), each 1 SD rise in SBP TTR cut AKI risk by 14% (HR:0.86)
- Higher TTR (59–100%) lowered AKI risk (HR:0.69), sustained SBP control, not intensity, was key to reducing AKI incidence.
22 Dec, 25Lancet Diabetes Endo...
- As per a meta-analysis of 4 trials (EMPA-REG OUTCOME, EMPEROR-Reduced, EMPEROR-Preserved, & EMPA-KIDNEY; n=23340), empagliflozin reduced the markers of AKI by 20% (HR: 0.80), AKI adverse events by 27% (HR: 0.73), CKD progression by 30% (HR: 0.70), & renal failure risk by 34% (HR: 0.66)
- The eGFR decline slowed by 64%, SGLT2 inhibition cut the risk of acute & chronic renal outcomes regardless of the acute eGFR dip.
19 Dec, 25Int Endod J.
- Patients with mature mandibular molars presenting with periapical lesions in the vit D grp received oral vit D supplements to raise serum 25(OH)D to 30–50 ng/mL vs 20–30 ng/mL in controls in this trial
- Vit D grp had significant reduction in lesion area after RCT (p<0.05) but fractal bone analysis & TNF α levels did not differ
- Optimal vit D accelerated periapical healing, supporting its role in teeth healing.
12 Dec, 25
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11 Dec, 25
Slide Library
Complex of Hybrid Diabetes Mellitus with Severe Insulin Resistance and Cerebrovascular Complications
11 Dec, 25
11 Dec, 25
9 Dec, 25
