Insights on non-insulin therapies for diabetes were presented at this session at EASD 2025.

In this session at EASD 2025 the novel classification system based on glycemic variability was discussed along with its effect on treatment responses and clinical outcomes.

Children born to mothers with hypertensive disorders of pregnancy had higher unadjusted risks of autism (OR 1.65), attention-deficit/hyperactivity disorder (1.27), intellectual disability (1.77), global developmental delay (1.77), and lower IQ (MD −2.20). Autism and developmental delay weakened after adjustments, but reduced IQ persisted, underscoring the need for early monitoring and intervention in these patients.

A study using 14 years of data found that patients ≥45 years with multiple psychiatric disorders had markedly higher odds of developing dementia. Two comorbidities doubled dementia risk (OR 2.3), while four raised it 11-fold (OR 11.1) vs. one disorder. Co-occurrence of mood and anxiety disorders carried the highest probability (48% to 89.6%). Early cognitive screening may enable timely risk reduction strategies.

In 848 adults with T1D using continuous glucose monitoring, time below range (TBR) alone did not predict 1-year incidence of severe hypoglycemic events (SHE). Over a year, 11.7% experienced SHE, but risk rose only in those with impaired awareness of hypoglycemia (IAH) along with high TBR70>6% (70 mg/dl; OR 3.32) or TBR54≥1% (54 mg/dl; OR 2.99). Assessing IAH alongside TBR could help identify high-risk patients.