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11 Mar, 26
New guidelines on pulmonary embolism (PE) offer evidence based recommendations for evaluating, managing, and following up adults with acute PE. Endorsed by eight societies, it stresses multidisciplinary care across emergency, inpatient, & outpatient settings.
26 Feb, 26
ADA 2026 outlines the standards for obesity pharmacotherapy. It recommends combining person-centered medication with lifestyle changes for adults with obesity. It details weight-loss targets and drug benefits for comorbidities
11 Mar, 26
JAMA Neurol.
- Dengue increased acute neurological events risk at 30 days vs uninfected cases: any new-incident neurological event (OR 9.69), memory loss (OR 3.19), movement disorders (OR 7.10), other neurological disorders (fatigue, encephalitis OR 14.32)
- Excess burden was modest (<1 excess event/100 cases)
- Risk was higher in adults ≥60 yrs & during DENV serotype 3 transmission (memory loss OR 2.99, movement disorders OR 6.38)
10 Mar, 26Am J Gastroenterol.
- Pediatric inflammatory bowel disease (IBD) incidence rose by 272% in a four decades, long-term study
- Ulcerative colitis (UC) was linked to increasing pancolitis, while Crohn’s disease (CD) cases shifted toward more ileocolonic (39.3%) & penetrating disease
- Median diagnosis age was 15.4 y and increased over time
- Thirteen percent of cases with a first degree relative with IBD, were diagnosed at a younger age.
10 Mar, 26Diabetes Res Clin Pr...
- In CHARLS (age ≥45, no prior stroke), baseline remnant cholesterol (RC) quartiles predicted 7 yr incident stroke (9.44%), adjusted HRs vs. Q1: 1.23, 1.39, 1.42
- Risk was significant in prediabetes & diabetes but not amongst those with normal glucose regulation, the risk was stronger when LDL C <130 mg/dL
- High RC independently predicted stroke in dysglycemia, suggesting it to be a therapeutic target beyond LDL C.
6 Mar, 26Cardiovasc Diabetol.
- In 6,847 metabolic dysfunction-associated steatotic liver disease (MASLD) patients (median follow-up 8.8 yrs), 19.6% died (6.5% CV, 1.3% diabetes)
- Higher estimated glucose disposal rate (eGDR) was linked to reduced all-cause (HR=0.94, P < 0.001), CV (HR=0.90, P < 0.001), & diabetes mortality (HR=0.70, P < 0.001)
- ROC AUCs: 0.606, 0.631, 0.729 respectively, eGDR shows prognostic relevance in MASLD.
2 Mar, 26
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